Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod.
BackgroundNeutrophils polarize and migrate in response to chemokines.Different types of membrane microdomains (rafts) have been postulated to be present in rear and front of polarized leukocytes and disruption of rafts by cholesterol sequestration prevents leukocyte polarization.Reggie/flotillin-1 and -2 are two highly homologous proteins that are